Copyright

(c) 2010-2024 Jon L Gelman, All Rights Reserved.
Showing posts with label Antibiotic resistance. Show all posts
Showing posts with label Antibiotic resistance. Show all posts

Monday, November 4, 2013

Roche to Pay Up to $548 Million for Antibiotic Against Superbug

Pharmaceutical costs are a major portion of the medical benefit delivery dollar. The economic costs for development and production are enormous for new pharmaceuticals. Government investment in costs of treatments as well as cures is essential. Today's post shared from businessweek.com reflects on the enormity of pharmaceutical costs.

Roche Holding AG (ROG) agreed to pay as much as 500 million Swiss francs ($548 million) for the rights to an experimental antibiotic to target a drug-resistant“superbug” that is a leading cause of fatal bacterial infections in hospitals.

Polyphor Ltd., the Allschwil, Switzerland-based developer of the antibiotic, will receive 35 million francs up front, and is eligible for further payments of as much as 465 million francs if the product meets development, regulatory and commercial goals, Roche said in an e-mailed statement today.Roche also will pay royalties on sales, the Basel, Switzerland-based company said.

The treatment, known as POL7080, targets Pseudomonas Aeruginosa, a bacterium that causes one in 10 hospital-acquired infections in the U.S., according to figures from the U.S.Centers for Disease Control and Prevention cited by Roche.Bacteria increasingly are growing resistant to antibiotics,leading to 25,000 deaths a year in the European Union alone,according to EU statistics.

“As the incidence of drug-resistant infections is creating an urgent demand for new therapeutic options, we look forward to adding this potentially important, targeted agent with a novel mechanism of action to our portfolio of innovative medicines,”said Janet Hammond, a Roche executive who oversees discovery of drugs for infectious diseases.

Polyphor, a closely held company, also is developing drugs for use in stem cell transplantation and lung diseases.

[Click here to see the rest of this post]

Friday, September 27, 2013

Antibiotic Resistant Threats in the US, 2013

Healthcare workers have something to worry about. Today's post is shared from the US CDC.

Threat Report 2013

This report, Antibiotic resistance threats in the United States, 2013 gives a first-ever snapshot of the burden and threats posed by the antibiotic-resistant germs having the most impact on human health
Each year in the United States, at least 2 million people become infected with bacteria that are resistant to antibiotics and at least 23,000 people die each year as a direct result of these infections. Many more people die from other conditions that were complicated by an antibiotic-resistant infection.
Antibiotic-resistant infections can happen anywhere. Data show that most happen in the general community; however, most deaths related to antibiotic resistance happen in healthcare settings such as hospitals and nursing homes.

Thursday, September 19, 2013

CDC: Antibiotic-resistant bugs sicken 2 million a year

Concern for the spread of infections has lead to a heightened sense of concern in the workplace. New electronic hand washing faucets, and the sprouting up of hand cleansing stations. Workers compensation continue to pay the price for the spread of infections. Today's post was shared by CIDRAP and comes from www.cidrap.umn.edu


The US Centers for Disease Control and Prevention (CDC) said today that antibiotic-resistant pathogens sicken 2 million Americans a year and listed the three most urgent threats as Clostridium difficile, carbapenem-resistant Enterobacteriaceae (CRE), and Neisseria gonorrhoeae.

The agency's first all-encompassing report on antibiotic disease threats spans 114 pages and ranks the pathogens in part to spur a multipronged effort to prioritize and battle the problems. Antibiotic-resistant microorganisms play a role in 23,000 deaths each year, the CDC said.
At a media briefing today, CDC Director Tom Frieden, MD, MPH, said the landmark report provides a snapshot of the antibiotic-resistant organisms that have the biggest impact on human health. He said the numbers are very conservative estimates that don't take into account infections that occur outside hospitals, such as nursing homes and dialysis centers.

The numbers are worrisome, because so few antibiotics to battle the new pathogens are in the development pipeline, he said. "If we don't take action early, the medicine cabinet will be empty for patients with life-threatening infections."

The CDC ranked the antibiotic-resistant organisms based on seven criteria: health impact, economic impact, how common the infection is, 10-year projection of how common it will become, ease of spread, antibiotic availability, and prevention barriers. It also grouped the organisms into three groups, based on threat level.

Topping the list is C...
[Click here to see the rest of this post]