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Showing posts with label nanotechnology. Show all posts
Showing posts with label nanotechnology. Show all posts

Tuesday, July 22, 2014

Ask Well: Nanoparticles in Sunscreens

Today's post is shared from nytimes.com. Workers' in an outdoor environment are exposed the the sun's rays. The question arises as to whether present protective measures, ie. sunscreens are more harmful than helpful.

Titanium dioxide nanoparticles have been used increasingly in sunscreens in the last decade to protect the skin because the tiny particles directly absorb the radiation from sunlight, especially in the UVB range. But because the articles are so tiny — generally about 100 nanometers across, compared with about 3,000 to 9,000 nanometers for a speck of dust — some scientists have raised concerns about whether they might do harm by seeping through the skin and into the bloodstream.

Concerns grew when studies in mice showed that when injected under the skin, titanium dioxide caused inflammation . In addition, the International Agency on Cancer Research, part of the World Health Organization, decided in 2006 to classify titanium dioxide as a potential human carcinogen, based mostly on inhalation studies in animals, though the group called the evidence “conflicting at best.”

But research has largely dismissed such concerns about absorption, and most experts say that sunscreens containing nanoparticles can be safely used.

More recently, concerns have focused on the possibility that these nanoparticles could promote skin aging....

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Wednesday, November 20, 2013

What Does Cancer Smell Like?

Nanotechnology is giving rise to concern for the safety of workers. The lack of regulation, statutes, Iand safety precautions result in deciduous and latent exposures. Today's post was shared by The New York Times and comes from www.nytimes.com

On a lab bench in Philadelphia sits a tiny box lined with nearly invisible nanotubes and gold. A clear plastic pipe runs through it, and a thicket of pins, each sprouting a red or blue wire, protrudes from its end. As air from the pipe wafts over the nanotubes, electrical signals surge out of the box along the wire threads. The whole apparatus is situated near a vial of blood, “sniffing” the air above it through the pipe.
The box, an electronic nose, is a key part of a theory being explored by George Preti, an organic chemist at the Monell Chemical Senses Center, and an interdisciplinary team that includes physicists and veterinarians at the University of Pennsylvania. Preti is an expert on human odors, having studied them for more than 40 years. He has sniffed — both with machines and with his nose — breath, sweat and other secretions in search of answers about why we smell the way we do. This latest project seeks to answer a question others might have never thought to ask: Does ovarian cancer have a smell?
In modern cancer medicine, doctors tend to rely on advanced imaging techniques and the detection of lumps. The widely acknowledged problem with these methods, though, is that by the time doctors have reason to order a scan or feel something, it’s often too late. Ovarian cancer has usually spread to other organs by the time it’s detected. If it is caught early — which happens only 15 percent of the time, often by accident when...
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Thursday, August 30, 2012

The threshold length for fibre-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma

Recent research implicates nanoparticles or nanofibres as a potential health hazard:

"Suspicion has been raised that high aspect ratio nanoparticles or nanofibres might possess asbestos-like pathogenicity. The pleural space is a specific target for disease in individuals exposed to asbestos and, by implication nanofibres. Pleural effects of fibres depends on fibre length, but the key threshold length beyond which adverse effects occur has never been identified up to now since all asbestos and vitreous fibre samples are heterogeneously distributed in their length. Nanotechnology advantageously allows for highly defined length distribution of synthetically engineered fibres which enable for in depth investigation of this threshold length. We utilised the ability to prepare silver-nanofibres of five defined length classes to demonstrate a threshold fibre length for acute pleural inflammation. Nickel-nanofibres and carbon nanotubes were then used to strengthen the relationship between fibre length and pleural inflammation. A method of intrapleural injection of nanofibres in female C57Bl/6 strain mice was used to deliver the fibre dose and we then assessed the acute pleural inflammatory response. Chestwall sections were examined by light and by scanning electron microscopy to identify areas of lesion; furthermore cell-nanowires interaction on the mesothelial surface of the parietal pleura in vivo, were investigated. Our results showed a clear threshold effect demonstrating that fibres beyond 4 µm in length are pathogenic to the pleura. The identification of the threshold length for nanofibre induced pathogenicity in the pleura has important implications for understanding the structure-toxicity relationship for asbestos-induced mesothelioma and consequent risk assessment with the aim to contribute to the engineering of synthetic nanofibres by the adoption of a benign-by-design approach."

Toxicol. Sci. (2012)doi: 10.1093/toxsci/kfs171First published online: May 12, 2012
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For over 3 decades the Law Offices of Jon L. Gelman  1.973.696.7900  jon@gelmans.com have been representing injured workers and their families who have suffered occupational accidents and illnesses.

Read more about nanotechnology
Sep 20, 2011
U.S. National Nanotechnology Initiative. Nano.gov: size of the nanoscale [http://www.nano.gov/nanotech-101/what/nano-size External Web Site Icon ]. U.S. National Nanotechnology Initiative. Nano.gov: Nanotechnology and ...
Aug 25, 2009
... following the publication of the September issue of the “European Respiratory Journal, the first medical case series of workers with serious disease that the study authors associate with exposure to nano-sized particles has ...

Tuesday, June 12, 2012

Nanomaterials: NIOSH Publishes Safe Practices Guide

NIOSH (The National Institute for Occupational Safety and Health) has published safety recommendations on engineering controls and safe practices for handling engineered nanomaterials in laboratories and some pilot scale operations. This guidance was designed to be used in tandem with well-established practices and the laboratory’s chemical hygiene plan. The introduction of nanoparticles into the workplace has created a new dimension in workers' compensation occupational exposure claims.

"Nanotechnology, the manipulation of matter at a nanometer scale to produce new materials, structures, and devices having new properties, may revolutionize life in the future. It has the potential to impact medicine through improved disease diagnosis and treatment technologies and to impact manufacturing by creating smaller, lighter, stronger, and more efficient products. Nanotechnology could potentially decrease the impact of pollution by improving methods for water purification or energy conservation. Although engineered nanomaterials present seemingly limitless possibilities, they bring with them new challenges for identifying and controlling potential safety and health risks to workers. Of particular concern is the growing body of evidence that occupational exposure to some engineered nanomaterials can cause adverse health effects.

"As with any new technology or new material, the earliest exposures will likely occur for those workers conducting discovery research in laboratories or developing production processes in pilot plants. The research community is at the front line of creating new nanomaterials, testing their usefulness in a variety of applications and determining their toxicological and environmental impacts. Researchers handling engineered nanomaterials in laboratories should perform that work in a manner that protects their safety and health. This guidance document provides the best information currently available on engineering controls and safe work practices to be followed when working with engineered nanomaterials in research laboratories.

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For over 3 decades the Law Offices of Jon L. Gelman1.973.696.7900 jon@gelmans.com have been representing injured workers and their families who have suffered work related accident and injuries.

Tuesday, September 20, 2011

US CDC Publishes Safety Nanotechnology Guidance

Citing concern over the occupational risks that potentially exist in nanotechnology, the US CDC has issued a safety guidance manual for the nanotechnology.


"Research has shown that materials on this small scale begin to exhibit physical, chemical, and biological behaviors that are quite unique. These unique properties raise concerns about the health impacts of nanotechnology, particularly among workers employed in nanotechnology-related industries."


References

U.S. National Nanotechnology Initiative. Nano.gov: size of the nanoscale [http://www.nano.gov/nanotech-101/what/nano-sizeExternal Web Site Icon].
U.S. National Nanotechnology Initiative. Nano.gov: Nanotechnology and you, benefits and applications. [http://www.nano.gov/you/nanotechnology-benefitsExternal Web Site Icon]. 
NIOSH [2010]. Nanotechnology Overview[ http://www.cdc.gov/niosh/topics/nanotech/]. 
International Organization for Standardization [2008]. ISO Standard 12885:2008 Nanotechnologies-Health and safety practices in occupational settings relevant to nanotechnologies.
Dahm MM, Yencken MS, Schubauer-Berigan, MK [in press]. Exposure control strategies in the carbonaceous nanomaterial industry. Journal of Occupational and Environmental 53(6S).
Roco M, Mirkin C, Hersam M [2010]. Nanotechnology research directions for societal needs in 2020: retrospective and outlook. Boston and Berlin: Springer. [http://wtec.org/nano2/External Web Site Icon].
NIOSH [2009]. Approaches to safe nanotechnology: managing the health and safety concerns associated with engineered nanomaterials. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication Number 2009-125. [http://www.cdc.gov/niosh/docs/2009-125/].

Thursday, October 28, 2010

Workers Compensation and Nanotechnology - The New Frontier

NIOSH research has revealed that breathing nanoparticles may result in damaging health effects.

"Nanotechnology has the potential to revolutionize countless products, create computers smaller and faster than once could be imagined, and fight diseases such as cancer. According to the Project on Emerging Nanotechnology, by the summer of 2009 there were 1,015 consumer products using nanotechnology. That represents nearly a 19-fold increase over the 54 products listed in 2005. Nanotechnology involves the manipulation of matter at a near-atomic scale. Nanoparticles measure from 1 to 100 nanometers in size, with 1 billion nanometers forming a meter. For comparison, a billion inches would nearly circle the Earth 2 times."
  • A 2004 survey estimatedthat nearly 25,000 U.S. workers were employed at businesses that exclusively produced nanotechnology products.
  • Nanoparticles can enter the body through many routes including inhalation, swallowing, ingestion, and absorption through the skin.
  • Nanotechnology may present health risks but it can also be used to protect workers. New respirator designs, for instance, use nanotechnology to create more effective filters to block harmful substances.
Authors of Inhalation Versus Aspiration of Single-Walled Carbon Nanotubes in C57BL/6 Mice: Inflammation, Fibrosis, Oxidative Stress, and Mutagenesis—Anna Shvedova, Elena Kisin, Ashley Murray, Victor Johnson, Olga Gorelik, Sivaram Arepalli, Ann Hubbs, Robert Mercer, Phouthone Keohavong, Nancy Sussman, J. Jin, J. Yin, Samuel Stone, The-hsun Chen, Gregory Deye, Andrew Maynard, Vince Castranova, Paul Baron, and Valerian Kagan; Health Effects Laboratory Division; NIOSH—received the 2009 Alice Hamilton Award in the Biological Sciences category.
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For over 3 decades the Law Offices of Jon L. Gelman 1.973.696.7900 jon@gelmans.com have been representing injured workers and their families who have suffered work related accident and injuries.

Tuesday, November 17, 2009

NIOSH Reports on the Safety of Nanotechnology

The emerging area of nanotechnology has brought with it concerns over worker safety. NIOSH has now released a progress report concerning this technology. NIOSH's goals are:

1. Determine whether nanoparticles and nanomaterials pose risks of work-related injuries and illnesses.
2. Conduct research to prevent work-related injuries and illnesses by ap- plying nanotechnology products.
3. Promote healthy workplaces through interventions, recommendations, and capacity building.
4. Enhance global workplace safety and health through national and international collaborations on nanotechnology research and guidance.

"To date, NIOSH/OEP has committed about $5.3 million dollars to research on applications and implications of nanotechnology. Summaries of the projects funded by NIOSH/OEP are included in Appendix B. NIOSH/OEP plans to continue collaborative efforts with EPA/NCER, NSF, NIH/NIEHS, and other international agencies to support nanotechnology research with occupational safety and health implications. OEP will continue to confer with the NIOSH Nanotechnology Research Center regarding issues, gaps, and future directions.

To read more about nanotechnology click here.