Today's post is shared from http://scienceblogs.com/ A new analysis of data from the world’s largest and longest-running study of women’s health finds that rotating night shift work is associated with higher mortality rates. The new findings add to a growing awareness that long-term night shift work comes with serious occupational health risks. Published this month in the American Journal of Preventive Medicine, the study found that all-cause and cardiovascular disease-related mortality were significantly increased among women who worked more than five years of rotating night shifts when compared to those who never worked the night shift. In addition, the study found that working 15 or more years of rotating night shifts was associated with a modest increase in lung cancer mortality. Previous research has also found a link between working the night shift and serious health risks. In fact, in 2007, the World Health Organization designated night shift work as a probable carcinogen, as it disrupts the physical, mental and behavioral changes that follow a daily cycle — otherwise known as circadian rhythms. Study authors Fangyi Gu, Jiali Han, Francine Laden, An Pan, Neil Caporaso, Meir Stampfer, Ichiro Kawachi, Kathryn Rexrode, Walter Willett, Susan Hankinson, Frank Speizer and Eva Schernhammer write: The circadian system and its prime marker, melatonin, are considered to have anti-tumor effects through multiple pathways, including antioxidant activity,... |
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Showing posts with label night shift work. Show all posts
Showing posts with label night shift work. Show all posts
Wednesday, January 7, 2015
Data from nurses’ study finds link between night shifts, higher mortality risk
Monday, March 10, 2014
Night Shift Work Causally Linked to an Increase in Breast Cancer
Working at night increases the risk of breast cancer according to a recent study.
Objectives The potential mechanisms that link night-shift work with breast cancer have been extensively discussed. Exposure to light at night (LAN) depletes melatonin that has oncostatic and anti-estrogenic properties and may lead to a modified expression of estrogen receptor (ER) α. Here, we explored the association between shift work and breast cancer in subgroups of patients with ER-positive and -negative tumors.
Methods GENICA (Gene–ENvironment Interaction and breast CAncer) is a population-based case–control study on breast cancer with detailed information on shift work from 857 breast cancer cases and 892 controls. ER status was assessed by immunohistochemical staining. Associations between night-shift work and ER-positive and -negative breast cancer were analyzed with conditional logistic regression models, adjusted for potential confounders.
Results ER status was assessed for 827 cases and was positive in 653 and negative in 174 breast tumors. Overall, 49 cases and 54 controls were “ever employed” in shift work including night shifts for ≥1 year. In total, “ever shift work” and “ever night work” were not associated with an elevated risk of ER-positive or -negative breast tumors. Night work for ≥20 years was associated with a significantly elevated risk of ER-negative breast cancer [odds ratio (OR) 4.73, 95% confidence interval (95% CI) 1.22–18.36].
Conclusions Our case–control study suggests that long-term night-shift work is associated with an increased risk of ER-negative breast cancers. Further studies on histological subtypes and the analysis of other potentially relevant factors are crucial for discovering putative mechanisms
Methods GENICA (Gene–ENvironment Interaction and breast CAncer) is a population-based case–control study on breast cancer with detailed information on shift work from 857 breast cancer cases and 892 controls. ER status was assessed by immunohistochemical staining. Associations between night-shift work and ER-positive and -negative breast cancer were analyzed with conditional logistic regression models, adjusted for potential confounders.
Results ER status was assessed for 827 cases and was positive in 653 and negative in 174 breast tumors. Overall, 49 cases and 54 controls were “ever employed” in shift work including night shifts for ≥1 year. In total, “ever shift work” and “ever night work” were not associated with an elevated risk of ER-positive or -negative breast tumors. Night work for ≥20 years was associated with a significantly elevated risk of ER-negative breast cancer [odds ratio (OR) 4.73, 95% confidence interval (95% CI) 1.22–18.36].
Conclusions Our case–control study suggests that long-term night-shift work is associated with an increased risk of ER-negative breast cancers. Further studies on histological subtypes and the analysis of other potentially relevant factors are crucial for discovering putative mechanisms
The report: Rabstein S, Harth V, Pesch B, Pallapies D, Lotz A, Justenhoven C, Baisch C,Schiffermann M, Haas S, Fischer H-P, Heinze E, Pierl C, Brauch H, Hamann U, Ko Y,Brüning T, "Night work and breast cancer estrogen receptor status – results from the German GENICA study", Scand J Work Environ Health 2013;39(5):448-455 doi:10.5271/sjweh.3360, 2010;36(2):163-179 2010;36(2):134-141
Read more ablout "breast cancer" and workers' compensation:
Jul 02, 2013
Objectives Long-term night work has been suggested as a risk factor for breast cancer; however, additional studies with more comprehensive methods of exposure assessment to capture the diversity of shift patterns are ...
Dec 15, 2012
A semiconductor plant worker, who had been exposed to solvents and radiation while working 5 years at a semiconductor factory in South Korea has been held to have suffered an compensable disease related to her ...
Mar 18, 2011
Fire fighters in Canada are supporting legislation that would establish a legal presumption that breast cancer is an occupationally related illness. The legislation also creates a presumption that 3 other cancers (skin, prostate ...
Dec 05, 2012
Breast Cancer and the Environment: A Life Course Approach - Institute of Medicine: "With more than 230,000 new cases of breast cancer expected to be diagnosed in the United States in 2011, many wonder about the role ...
Thursday, September 5, 2013
NIOSH Research on Work Schedules and Work-related Sleep Loss
Nurses/Reproduction Issues/Shift WorkNIOSH studies are examining shift work and physical demands with respect to adverse pregnancy outcome among nurses, specifically the association between work schedule and risk of spontaneous abortion, preterm birth, and menstrual function.This research was the first to look at shift work and pregnancy in U. S. nurses. NIOSH researchers are collaborating with the Harvard Nurses’ Health Study, which is the largest, ongoing prospective study of nurses. Results have shown that an increased risk of several reproductive outcomes, including spontaneous abortion, early preterm birth, and menstrual cycle irregularities, are related to shift work, particularly working the night shift. In addition, results show independent effects on reproductive outcomes from long working hours. The study hopes to establish a cohort of over 100,000 female nurses of... |
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Jon L. Gelman of Wayne NJ is the author NJ Workers’ Compensation Law (West-Thompson) and co-author of the national treatise, Modern Workers’ Compensation Law (West-Thompson). For over 4 decades the Law Offices of Jon L Gelman 1.973.696.7900 jon@gelmans.com have been representing injured workers and their families who have suffered occupational accidents and illnesses.
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Tuesday, September 3, 2013
Night Shift Work Causally Linked to an Increase in Breast Cancer
By Jon Gelman from Jon L Gelman LLC
Working at night increases the risk of breast cancer according to a recent study.
Objectives The potential mechanisms that link night-shift work with breast cancer have been extensively discussed. Exposure to light at night (LAN) depletes melatonin that has oncostatic and anti-estrogenic properties and may lead to a modified expression of estrogen receptor (ER) α. Here, we explored the association between shift work and breast cancer in subgroups of patients with ER-positive and -negative tumors.
Methods GENICA (Gene–ENvironment Interaction and breast CAncer) is a population-based case–control study on breast cancer with detailed information on shift work from 857 breast cancer cases and 892 controls. ER status was assessed by immunohistochemical staining. Associations between night-shift work and ER-positive and -negative breast cancer were analyzed with conditional logistic regression models, adjusted for potential confounders.
Results ER status was assessed for 827 cases and was positive in 653 and negative in 174 breast tumors. Overall, 49 cases and 54 controls were “ever employed” in shift work including night shifts for ≥1 year. In total, “ever shift work” and “ever night work” were not associated with an elevated risk of ER-positive or -negative breast tumors. Night work for ≥20 years was associated with a significantly elevated risk of ER-negative breast cancer [odds ratio (OR) 4.73, 95% confidence interval (95% CI) 1.22–18.36].
Conclusions Our case–control study suggests that long-term night-shift work is associated with an increased risk of ER-negative breast cancers. Further studies on histological subtypes and the analysis of other potentially relevant factors are crucial for discovering putative mechanisms
The report: Rabstein S, Harth V, Pesch B, Pallapies D, Lotz A, Justenhoven C, Baisch C,Schiffermann M, Haas S, Fischer H-P, Heinze E, Pierl C, Brauch H, Hamann U, Ko Y,Brüning T, "Night work and breast cancer estrogen receptor status – results from the German GENICA study", Scand J Work Environ Health 2013;39(5):448-455 doi:10.5271/sjweh.3360, 2010;36(2):163-179 2010;36(2):134-141
Read more about "breast cancer" and workers' compensation:
Jul 02, 2013
Objectives Long-term night work has been suggested as a risk factor for breast cancer; however, additional studies with more comprehensive methods of exposure assessment to capture the diversity of shift patterns are ...
Dec 15, 2012
A semiconductor plant worker, who had been exposed to solvents and radiation while working 5 years at a semiconductor factory in South Korea has been held to have suffered an compensable disease related to her ...
Mar 18, 2011
Fire fighters in Canada are supporting legislation that would establish a legal presumption that breast cancer is an occupationally related illness. The legislation also creates a presumption that 3 other cancers (skin, prostate ...
Dec 05, 2012
Breast Cancer and the Environment: A Life Course Approach - Institute of Medicine: "With more than 230,000 new cases of breast cancer expected to be diagnosed in the United States in 2011, many wonder about the role ...
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