Cardiologists have accused a small drug company of withholding data from a clinical trial showing that the company’s drug, meant to reduce the risk of heart attacks, increased the risk instead.
The cardiologists said that the company, Anthera Pharmaceuticals, did not turn over data to academic investigators, as it was required to do, for more than a year.
“Despite a contract that required transfer to the academic authors, the company stonewalled every attempt to acquire the data,” Dr. Steven Nissen, a cardiologist at the Cleveland Clinic, said in an email on Tuesday.
Dr. Nissen was the senior author of a report on the data that was published online Monday by The Journal of the American Medical Association and presented at the annual meeting of the American Heart Association in Dallas. In unveiling the results there, the lead investigator, Dr. Stephen Nicholls, publicly admonished the company.
Dr. Colin Hislop, the chief medical officer at Anthera, denied the accusations, saying it simply took time to gather and organize the data. “I don’t think the timeline was particularly protracted, nor were we being difficult,” he said in an interview Tuesday.
Studies and lawsuits have shown that many clinical trial results, particularly negative ones, are not published. Critics say that hampers medical practice and violates an obligation to patients, who try experimental treatments in part to advance knowledge.
“We think that when you enter...
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Showing posts with label JAMA (journal). Show all posts
Showing posts with label JAMA (journal). Show all posts
Sunday, November 24, 2013
Doctors Say Heart Drug Raised Risk of an Attack
Saturday, September 21, 2013
Workplace Stress, Depression, and the Overuse of Antidepressant Drugs in the Workplace
Medication side effects are the #4 leading cause of death in the U.S. annually (JAMA 1998). Yet, few people receive adequate information when medication is prescribed. This website is dedicated to providing information to help you and your doctor make informed, intelligent choices about medications and natural alternatives to maximize the benefits and minimize the risks of treatment. An Interview with Dr. Richard Lippin, an Expert on Occupational and Environmental MedicineDr. Cohen: Dr. Lippin, for many years you have been concerned about stress and depression in the workplace and the use of antidepressants medications. Why?Dr. Lippin: As an administrator and doctor in occupational health settings for over 30 years, I've seen many depressed workers. This is a huge, growing, well-documented problem. Of the 47 million Americans who suffer from depression, probably over 70% or about 33 million are part of the nation's workforce. Depression costs employers $44 billion a year in lost productive time... |
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