Novel cancer vaccine holds promise against ovarian cancer, mesothelioma

Today's post is shared from the Massachusetts General Hospital and sciencedaily.com.

A novel approach to cancer immunotherapy may provide a new and cost-effective weapon against some of the most deadly tumors, including ovarian cancer and mesothelioma. Investigators report that a protein engineered to combine a molecule targeting a tumor-cell-surface antigen with another protein that stimulates several immune functions prolonged survival in animal models of both tumor.

A novel approach to cancer immunotherapy -- strategies designed to induce the immune system to attack cancer cells -- may provide a new and cost-effective weapon against some of the most deadly tumors, including ovarian cancer and mesothelioma. Investigators from the Massachusetts General Hospital (MGH) Vaccine and Immunotherapy Center report in the Journal of Hematology & Oncology that a protein engineered to combine a molecule targeting a tumor-cell-surface antigen with another protein that stimulates several immune functions prolonged survival in animal models of both tumors.

"Some approaches to creating cancer vaccines begin by extracting a patient's own immune cells, priming them with tumor antigens and returning them to the patient, a process that is complex and expensive," says Mark Poznansky, MD, PhD, director of the MGH Vaccine and Immunotherapy Center and senior author of the report. "Our study describes a very practical, potentially broadly applicable and low-cost approach that could be used by oncologists everywhere, not just in facilities able to harvest and handle patient's cells.

The MGH team's vaccine stimulates the patient's own dendritic cells, a type of immune cell that monitors an organism's internal environment for the presence of viruses or bacteria, ingests and digests pathogens encountered, and displays antigens from those pathogens on their surface to direct the activity of other immune cells. As noted above, existing cancer vaccines that use dendritic cells require extracting cells from a patient's blood, treating them with an engineered protein or nucleic acid that combines tumor antigens with immune-stimulating molecules, and returning the activated dendritic cells to the patient.

The approach developed by the MGH team starts with the engineered protein, which in this case fuses an antibody fragment targeting a protein called mesothelin -- expressed on the surface of such tumors as mesothelioma, ovarian cancer and pancreatic cancer -- to a protein from the tuberculosis bacteria that stimulates the activity of dendritic and other immune cells. In this system, the dendritic cells are activated and targeted against tumor cells while remaining inside the patient's body.

In the experiments described in the paper, the MGH team confirmed that their mesothelin-targeting fusion protein binds to mesothelin on either ovarian cancer or mesothelioma cells, activates dendritic cells, and enhances the cells' processing and presentation of several different tumor antigens, inducing a number of T-cell-based immune responses. In mouse models of both tumors, treatment with the fusion protein significantly slowed tumor growth and extended survival, probably through the activity of cytotoxic CD8 T cells.

"Many patients with advanced cancers don't have enough functioning immune cells to be harvested to make a vaccine, but our protein can be made in unlimited amounts to work with the immune cells patients have remaining," explains study co-author Jeffrey Gelfand, MD, senior scientist at the Vaccine and Immunotherapy Center. "We have created a potentially much less expensive approach to making a therapeutic cancer vaccine that, while targeting a single tumor antigen, generates an immune response against multiple antigens. Now if we can combine this with newly-described ways to remove the immune system's "brakes" -- regulatory functions that normally suppress persistent T-cell activity -- the combination could dramatically enhance cancer immunotherapy."

Poznansky adds that the tumors that might be treated with the mesothelin-targeting vaccine -- ovarian cancer, pancreatic cancer and mesothelioma -- all have poor survival rates. "Immunotherapy is generally nontoxic, so this vaccine has the potential of safely extending survival and reducing the effects of these tumors, possibly even cutting the risk of recurrence. We believe that this approach could ultimately be used to target any type of cancer and are currently investigating an improved targeting approach using personalized antigens." The MGH team just received a two-year grant from the Department of Defense Congressionally Directed Medical Research Program to continue their research.

Journal Reference:
Jianping Yuan, Satoshi Kashiwagi, Patrick Reeves, Jean Nezivar, Yuan Yang, Nadiah Arrifin, Mai Nguyen, Gilberte Jean-Mary, Xiaoyun Tong, Paramjit Uppal, Svetlana Korochkina, Ben Forbes, Tao Chen, Elda Righi, Roderick Bronson, Huabiao Chen, Sandra Orsulic, Timothy Brauns, Pierre Leblanc, Nathalie Scholler, Glenn Dranoff, Jeffrey Gelfand, Mark C Poznansky. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. Journal of Hematology & Oncology, 2014; 7 (1): 15 DOI:10.1186/1756-8722-7-15

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EPA Fines Arizona School Districts for Asbestos Violation

The U.S. Environmental Protection Agency has fined six Arizona school districts a combined total of $94,575 for Asbestos Hazard Emergency Response Act (AHERA) violations. More than 15,000 children attend the 25 schools not in compliance with the federal AHERA in these districts. 

During inspections conducted in 2011, EPA inspectors discovered numerous violations, from failing to inspect facilities for asbestos containing materials, failing to re-inspect campuses with known asbestos containing materials, and failing to have an Asbestos Management Plan. All of the school districts have since taken necessary actions to comply with the law, with the cost of compliance reducing the penalties in most cases to zero. 

“Asbestos in schools has the potential to harm the health of students, teachers, and maintenance workers,” said Jared Blumenfeld, EPA’s Regional Administrator for the Pacific Southwest. “EPA takes these violations seriously, and we are satisfied the schools have now conducted inspections and put their asbestos plans in place.” 

Each school district is allowed to subtract properly documented costs of complying with the regulations from the penalty amount. The six school districts are: 
· Apache Junction Unified School District (Pinal County): fined $21,675, but this was reduced to $7,933 because of the school district’s cost of achieving compliance. 
· St. John’s Unified School District (Apache County): fined $14,195, reduced to $824 by the school district’s cost of achieving compliance.
· Florence Unified School District (Pinal County): fined $31,705, but no cash payment was due because the documented costs of compliance exceeded the penalty. 
· Vernon Elementary School District (Apache County): fined $2,700, but no cash payment was due because the documented costs of compliance exceeded the penalty. 
· McNary Elementary School District (Fort Apache Indian Reservation): fined $14,200, but no cash payment was due because the documented costs of compliance exceeded the penalty.
· Round Valley Unified School District (Apache County): fined $10,100, but no cash payment was due because the documented costs of compliance exceeded the penalty.
Federal law requires schools to conduct an initial inspection using accredited inspectors to determine if asbestos-containing building material is present and develop a management plan to address the asbestos materials found in the school buildings. Schools are also required to appoint a designated person who is trained to oversee asbestos activities and ensure compliance with federal regulations. Finally, schools must conduct periodic surveillance and re-inspections of asbestos-containing building material, properly train the maintenance and custodial staff, and maintain records in the management plan.

Local education agencies must keep an updated copy of the management plan in its administrative office and at the school which must be made available for inspection by parents, teachers, and the general public.

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Canada Concedes Asbestos is Dangerous-Now It Needs to Ban Asbestos Entirely

Canada's Industry Minister announced yesterday that the country would finally concede to international pressure and label asbestos that it exports as a health hazard. Now Canada, and the United States, need to take the next step and impose a universal ban against the use and sale of asbestos products.

Asbestos is a known carcinogen and causally related to mesothelioma and lung cancer. For decades asbestos was mined and exported from the Province of Quebec.

Click here to read Ottawa does U-turn on asbestos mining (Globe & Mail)

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Demolition Contractors Indicted for Unlicensed and Unsafe Asbestos Removal at Zurbrugg Hospital Site in Riverside NJ

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NJ Attorney General Jeffrey S. Chiesa announced that two men and the demolition company they operated have been indicted by a state grand jury on charges that they unlawfully removed asbestos from the former Zurbrugg Memorial Hospital in Riverside, N.J., without a license, using workers who were not trained or equipped to do the job safely.
The Division of Criminal Justice obtained a state grand jury indictment charging Frank J. Rizzo, 53, of Parlin, Michael Kouvaras, 59, of Maplewood, and the company they ran, Deuteron Capital, LLC, doing business as South Street Fillit Recycling of Riverside, with conspiracy (2nd degree), unlawfully causing the release of a toxic pollutant (2nd degree), abandonment of toxic pollutants (2nd degree), and violating the Asbestos Control and Licensing Act (3rd degree). The charges stem from a joint investigation by the Division of Criminal Justice Environmental Crimes Unit and the Department of Corrections Special Investigations Division.


Between August 2010 and March 2011, the defendants allegedly used untrained day laborers, including inmates from a halfway house, to remove asbestos from the hospital buildings in connection with demolition at the site and their efforts to salvage valuable copper and steel. They allegedly engaged in asbestos removal without the required license from the New Jersey Department of Labor, and their illegal activities allegedly caused the release of asbestos dust and debris. Kouvaras, the owner of South Street, and Rizzo, the project organizer, allegedly directed unlicensed workers to remove asbestos or asbestos-containing material, bury approximately 50 bags of asbestos in the ground, and dump bags of asbestos on the floor of a boiler room so that it would appear that vandals had removed the asbestos while stealing copper and steel.


“These men knew there was asbestos throughout this old hospital and knew the real dangers involved in removing it, but we allege that they put their monetary self-interest ahead of the health and safety of their workers and the surrounding community,” said Attorney General Chiesa. “They are charged with serious crimes, including second-degree offenses that carry a sentence of five to 10 years in state prison.”


“Through our Environmental Crimes Unit, we have made prosecuting polluters a high priority,” said Stephen J. Taylor, Director of the Division of Criminal Justice. “The laws and regulations governing the handling and disposal of hazardous materials such as asbestos are there to protect all of us, and we will come down hard on violators who put workers and the public at risk.”


In early 2010, Rizzo solicited the owner of the Zurbrugg site for the contract to demolish the hospital. South Street was given the contract, which specified that the company would retain all of the proceeds from the recycling of metal and arrange for and pay all demolition costs, including asbestos abatement and disposal. An engineering report on the hospital buildings, which was provided to the defendants, identified extensive asbestos throughout the structures.


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The defendants allegedly used day laborers, including inmates from Clinton House, a work release halfway house in Trenton, to remove asbestos from sections of the hospital, without following the requirements of federal and state laws to prevent the release of toxic asbestos dust and debris. For example, the workers stripped insulation containing asbestos from pipes and a boiler, so that copper pipes, wire and other metals could be salvaged. It is alleged that the workers did not wear protective equipment, with the exception of paper masks, which are not authorized as safe for asbestos removal. The workers quickly took off the paper masks because the masks made it difficult to breathe.


The workers placed materials containing asbestos into black plastic bags, and some of the bags were placed in a roll-off container provided by a waste transportation company. Disposal manifests show 25 bags and 100 bags respectively were removed by a licensed hauler and disposed of at a lawful facility.


Division of Criminal Justice detectives executed a search warrant at the site on Filmore Street on March 28, 2011, and discovered material containing asbestos strewn on the floor of the boiler room. They found a roll-off container holding over 200 plastic bags of materials, 30 of which were tested and found to contain asbestos. They also uncovered two bags containing asbestos tiles buried in the ground during limited excavation at the site.
The U.S. Environmental Protection Agency Region 2 has taken jurisdiction of the site, which is being evaluated for asbestos removal action.


The state investigation began in early 2011 when the Department of Corrections (DOC) Special Investigations Division received a tip that inmates were being used to remove asbestos at the site. DOC alerted the Division of Criminal Justice, which joined the investigation. The Department of Environmental Protection, Department of Health & Senior Services and Department of Labor & Workforce Development assisted with the investigation, including helping with the execution of search warrants at the Zurbrugg site and South Street offices beginning on March 28, 2011.


Supervising Deputy Attorney General Betty Rodriguez and Deputy Attorney General Mary Erin McAnally presented the case to the state grand jury. The investigation was conducted for the Environmental Crimes Unit, within the Division of Criminal Justice Specialized Crimes Bureau, by Sgt. Steven Ogulin, Detective Dawn Ryan, Detective Michael Klumpp, SDAG Rodriguez and DAG McAnally. The investigation was led for the Department of Corrections Special Investigations Division by Principal Investigator Daniel Klotz.
Second-degree crimes carry a sentence of five to 10 years in state prison and a fine of up to $150,000. The third-degree offense of violating the Asbestos Control and Licensing Act carries a sentence of three to five years in prison and a fine of up to $25,000. The indictment is merely an accusation and the defendants are presumed innocent until proven guilty.


The indictment was handed up to Superior Court Judge Thomas W. Sumners Jr. in Mercer County, who assigned it to Burlington County. The indictment is posted with this release at www.njpublicsafety.com.
....
For over 3 decades the Law Offices of Jon L. Gelman1.973.696.7900 jon@gelmans.com have been representing injured workers and their families who have suffered work related accident and injuries.

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Childrens Asthma Caused By Pregnant Mothers Occupational Exposure

A recent study of pregnant working women reveals that their exposure to occupational pollution results in their children's development of asthma. The report was presented at the Eastern European Respiratory's annual meeting in Amsterdam. "The results indicate an association between maternal occupational work exposures and the risk of asthma in the child at age 7 years. "

Reuters reported: "In a Danish review of registry data on 45,658 seven-year-old children and their mothers, 18.6 percent of children of mothers who were exposed to low-molecular-weight particles and irritants at work during pregnancy contracted asthma, compared to 16.1 percent of the general population."

See: Mothers work exposure during pregnancy and asthma in their children, a prospective cohort-study; B. H. Christensen, A. D. Larsen, L. R. Skadhauge, A. M. Thulstrup, K. S. Hougaard, K. S. Hansen, M. Frydenberg, V. Schlünssen (Aarhus, Copenhagen, Esbjerg, Gentofte, Denmark)

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Jack McConnell Confirmed by U.S. Senate as US District Court Judge

We are proud to announce that our national asbestos co-counsel, John J. McConnell, Jr., has been confirmed by the U.S. Senate Judiciary Committee following his nomination by President Obama to serve on the federal bench in Rhode Island. If selected, he will replace retiring U.S. District Judge Ernest C. Torres in the U.S. District Court for the District of Rhode Island.  

For over a quarter of a century, Jack has worked with our office in handling many cases, including asbestos litigation matters. His legal brilliance and insight as a trial attorney resulted in a verdict of $5.8 Million in a Federal court trial against Keene Corp., an asbestos producer. It was the largest single damage verdict in the US at the time. His superior negotiation ability coupled with his endless compassion for the victims of asbestos related illnesses, and their families, has resulted in the favorable resolution of hundreds of claims.

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NIOSH Issues "Roadmap" Document Suggesting Asbestos Research Strategy

The National Institute for Occupational Safety and Health (NIOSH) announces the availability of “Current Intelligence Bulletin: Asbestos Fibers and Other Elongate Mineral Particles: State of the Science and Roadmap for Research.” The document contains NIOSH’s recommended framework for a national research strategy to address current scientific uncertainties about occupational exposure and toxicity issues relating to asbestos fibers and other elongate mineral particles.

The Current Intelligence Bulletin is available online at www.cdc.gov/niosh/docs/2011-159/.

It is well documented that asbestos fibers can cause lung cancer and other types of serious lung disease in workers when inhaled. Since the passage of the Occupational Safety and Health Act in 1970, considerable progress has been made in preventing harmful exposures and protecting workers from risks of illness. However, many scientific uncertainties remain as to the health risks associated with exposure to other elongate mineral particles, including those with mineralogical compositions identical or similar to the asbestos minerals and those that have already been documented to cause asbestos-like disease, as well as the physical and chemical characteristics that determine toxicity.

The new NIOSH document incorporates extensive public comment and scientific peer review, including review by an independent committee of the Institute of Medicine and the National Research Council. The document does not set any new NIOSH policy regarding asbestos fibers and other elongate mineral particles.

“The NIOSH roadmap outlines a strategic framework for designing, conducting, and applying the research that will best serve the need to address persistent scientific uncertainties about occupational health and elongate mineral particles,” said NIOSH Director John Howard, M.D. “We look forward to working with our partners to advance this research, building on today’s state-of-the-art scientific tools and methodologies.”

Priority areas for research, as proposed by the roadmap, include:

• Developing a broader understanding of the factors that determine the toxicity of asbestos fibers and other elongate mineral particles.
• Developing information and knowledge on occupational exposures to asbestos fibers and other elongate mineral particles, and related health outcomes.
• Development of improved sampling and analytical methods for asbestos fibers and other elongate mineral particles.
• Applying research outcomes to improve public policy.

NIOSH is the federal agency that conducts research and makes recommendations for preventing work-related injury, illness, and death. NIOSH has a longstanding program of research and health surveillance to prevent asbestos-related disease, and its scientific findings and recommendations have contributed significantly to national policies for eliminating or minimizing harmful exposures. Further information is available at www.cdc.gov/niosh/topics/asbestos/.

For over 3 decades the Law Offices of Jon L. Gelman  1.973.696.7900  jon@gelmans.com have been representing injured workers and their families who have suffered asbestos related disease.

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New Drug May Be Effective Against Mesothelioma

Recent research by Japanese scientists have been reported effective against malignant pleural mesothelioma [MPM], a rare cancer associated with asbestos exposure. The drug, named S-1, has been developed as a novel oral antineoplastic agent "based on the modulation of 5-fluorouracil (5-FU) bioactivity."

The scientists used three human MPM cell lines, Y-MESO-14, NCI-H290 and MSTO-211H. In vitro proliferation of human MPM cells was determined by MTT assay. Human MPM cells were orthotopically implanted into thoracic cavity of SCID mice. Tumor-bearing mice were treated with S-1 or vehicle.

"The combination of 5-FU and 5-chloro-2,4-dihydroxypyridine (CDHP) was more effective than 5-FU alone in inhibiting MPM cell proliferation in vitro. This combination was most effective in Y-MESO-14 cells, which co-expressed high protein level of dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP). In vivo data showed that treatment with S-1 significantly reduced thoracic tumors and pleural effusion produced by Y-MESO-14 cells. Moreover, treatment with S-1 prolonged the survival of Y-MESO-14 cell-bearing SCID mice."

They concluded, "We demonstrated that S-1 was effective for inhibiting the proliferation of MPM cells, particularly with both DPD and TP expressions, suggesting that S-1 might be therapeutically effective for control of MPM."

CANCER CHEMOTHERAPY AND PHARMACOLOGY DOI: 10.1007/s00280-010-1503-x

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Asbestos Used by Brake Workers Linked to Malignant Mesothelioma

A recent study published in the Annals of Occupational Hygiene finds that exposure to chrysotile asbestos fiber manufactured by a friction materials factory, Raybestos Manhattan Inc., was causally to malignant mesothelioma, a rare and fatal disease. This appears to be consistent with the association previously established among Quebec asbestos miners and at a South Carolina asbestos textile factory. 


Raybestos Manhattan formerly had many frictional materials plants in operation throughout the US. One facility was located in Passaic NJ. That plant closed in June of 1975. Hundreds of workers' compensation claims were filed by the former workers who suffered from illnesses as a result of the exposure to asbestos fiber. Claims were also filed against the manufacturers and distributors of asbestos products including the asbestos mines in Quebec. 


Annals of Occupational Hygiene, doi:10.1093/annhyg/meq046 


Click here to read more about asbestos related disease and claims for benefits. For over 3 decades the Law Offices of Jon L. Gelman 1.973.696.7900 jon@gelmans.com  have been representing injured workers and their families who have suffered asbestos related illnesses.

Asbestos Manufacturer Circor - Leslie Files for Bankruptcy Protection

Circor International, Inc. (NYSE: CIR) today announced a major development in its effort to stem mounting asbestos litigation costs and resolve asbestos liability claims at its Leslie Controls, Inc. subsidiary.

Leslie today filed a pre-negotiated plan of reorganization as a voluntary petition under Chapter 11 of the U.S. Bankruptcy Code in U.S. Bankruptcy Court for the District of Delaware. Supported by a committee of attorneys representing current asbestos claimants and a proposed independent representative of future claimants, the plan is intended to permanently resolve Leslie’s asbestos liability through the creation of a trust pursuant to Section 524(g) of the U.S. Bankruptcy Code. All current and future asbestos claims against Leslie would be channeled to the trust for review and payment, thus providing both Leslie and CIRCOR with permanent court protection from such claims.

“Because we strongly believe that exposure to Leslie’s products has not caused any asbestos-related illness, our strategy has been to vigorously defend these claims,” said CIRCOR Chairman and Chief Executive Officer Bill Higgins. “However, the cost of this defense has exceeded the profits generated by Leslie’s operations, and we have been considering for some time a range of strategic alternatives that would enable us to permanently eliminate this expense and risk. Resolving Leslie’s asbestos liability through a pre-negotiated plan of reorganization accomplishes that aim, while preserving the value of a strong and viable business.”

Asbestos is a known cancer causing agent and has been linked to asbestosis and mesothelioma.

“We believe that a 524(g) trust that equitably resolves all pending and future claims and provides CIRCOR with permanent protection from derivative claims is in the best interest of all our stakeholders, including CIRCOR’s shareholders and Leslie’s customers, suppliers and employees,” Higgins continued. “Unencumbered by financial and legal exposure to asbestos liability, Leslie will be positioned to grow and contribute to CIRCOR’s profitability and cash flow going forward.”

Leslie intends to conduct business as usual during the Chapter 11 process, which could be completed in as little as 120 days., Today’s filing stays all pending and future asbestos litigation against Leslie. As a result, Leslie expects that its cash from operations will be sufficient to satisfy all of its operating obligations during this period. In addition, debtor-in-possession financing has been arranged for Leslie if needed.

Key terms of the pre-negotiated plan are as follows:
Funding for the 524(g) trust will consist of a $75 million contribution by Leslie andCIRCOR together with a contribution of proceeds from Leslie’s remaining asbestos insurance assets;
A provision that permanently protects CIRCOR and its affiliates from future derivative claims associated with Leslie’s asbestos liability; and
Leslie will remain a subsidiary of CIRCOR during and after Chapter 11.

Click here to read more about asbestos related disease and claims for benefits. For over 3 decades the Law Offices of Jon L. Gelman1.973.696.7900 jon@gelmans.com  have been representing injured workers and their families who have suffered asbestos related illnesses.

Lawsuit Filled Alleging Asbestos Exposed Chemical Worker Suffered Fatal Mesothelioma

A lawsuit was filed alleging that a former chemical operator at Hoffman-LaRoche in Nutley, New Jersey was exposed to asbestos fiber and died of mesothelioma. The lawsuit filed in New Jersey Superior Court asserts that he suffered injurious exposure to asbestos as a direct result of his exposure to asbestos fiber at work. The estate of the deceased worker brought the action against several manufacturers and suppliers of asbestos fiber.

The lawsuit, Huk v Bird, Inc., was filed Friday in the Superior Court of New Jersey by the law 
firm of Jon L. Gelman LLC, and Motley Rice LLC , on behalf of estate. It alleges that those companies that mined, processed and sold asbestos-containing products were knowledgeable about the harmful effects of exposure to asbestos and asbestos-containing products, and failed to provide those exposed with knowledge as to possible precautions to protect against the harmful effects of asbestos exposure.

Mesothelioma is a rare cancer associated with asbestos exposure. The rates asbestos related fatalities are predicted to continue for decades to come. Despite public outcry, and the urging of physicians, asbestos is still not banned in the United States.

Attorney Jon L. Gelman, who has been litigating asbestos exposure claims for over three decades, said, “It is alleged the asbestos companies put into the stream of commerce a defective, unsafe and inherently dangerous product and failed to provide reasonable warnings.”

The defendants are Bird, Inc., Certain-Teed Corp., Frank A. McBride Company, Owens-Illinois, Inc and Rapid American Corporation.

Attorney Contact: Jon L. Gelman of Jon L. Gelman LLC, Wayne, NJ, 973.696.7900 or visit www.gelmans.com.

Allianz Firemans Fund Increases Asbestos Reserves by $301 Million

Fireman's Fund Insurance Company a Division of Allianz has announced that it will increase its asbestos and environmental risks reserve by $301 Million. The company stated, "The move follows the completion of its regular independent external asbestos exposure review."


Asbestos has been a known carcinogen for decades. It is a natural occurring mineral that that has been used for its non-flammable properties. Medical conditions occur such as asbestosis, mesothelioma and other cancers, decades after the initial exposure.


Initially sold by companies in the 1920s, without warning of its known dangers, asbestos use continues not to be banned in the US. Disease from asbestos exposure is predicted to continue at very high rates.

 The largest transfer of economic wealth in the United States from Industry to the private sector, other than in the Attorney General’s thirty-eight State tobacco litigation, emanated from asbestos litigation which had its geneses in workers’ compensation.   The late Irving Selikoff, MD’s pioneering efforts in providing expert testimony, based upon his sentinel studies of asbestos workers in Paterson, NJ, created the trigger mechanism for a massive wave of claims for occupational health care. The workers' compensation program never did adequately nor efficiently or expeditiously provide medical care.

The workers’ compensation system did not provide an adequate remedy because of a constellation of reasons, and subsequently, the wave spread to civil litigation out of desperation for adequate benefits. Asbestos litigation has been named, "The Longest Running Tort” in American history.   Asbestos litigation expanded into  bankruptcy claims that continue unabated and the epidemic of disease continues. The remaining cases in the Federal court system were transferred to Federal Multi District Litigation (MDL 875) and the majority are finally concluding after twenty years of Panel consolidation.


Large verdicts continue to be reported in asbestos claims. A Los Angles jury recently awarded $208.8 Million in what has been recognized as the largest asbestos verdict ($200 Million punitive damages) in the State of California.  The case involved a household contact exposure to asbestos fiber. The wife of the asbestos worker was exposed to asbestos fiber on the clothes of her husband that he brought home and that she cleaned.


Click here to read more about asbestos related disease and claims for benefits. For over 3 decades the Law Offices of Jon L. Gelman1.973.696.7900 jon@gelmans.com  have been representing injured workers and their families who have suffered asbestos related illnesses.

New Study Released Explaining the Asbestos - Mesothelioma Link

"Asbestos carcinogenesis has been linked to the release of cytokines and mutagenic reactive oxygen species (ROS) from inflammatory cells. Asbestos is cytotoxic to human mesothelial cells (HM), which appears counterintuitive for a carcinogen. We show that asbestos-induced HM cell death is a regulated form of necrosis that links to carcinogenesis. Asbestos-exposed HM activate poly(ADP-ribose) polymerase, secrete H2O2, deplete ATP, and translocate high-mobility group box 1 protein (HMGB1) from the nucleus to the cytoplasm, and into the extracellular space. The release of HMGB1 induces macrophages to secrete TNF-α, which protects HM from asbestos-induced cell death and triggers a chronic inflammatory response; both favor HM transformation. In both mice and hamsters injected with asbestos, HMGB1 was specifically detected in the nuclei, cytoplasm, and extracellular space of mesothelial and inflammatory cells around asbestos deposits. TNF-α was coexpressed in the same areas. HMGB1 levels in asbestos-exposed individuals were significantly higher than in nonexposed controls (P < 0.0001). Our findings identify the release of HMGB1 as a critical initial step in the pathogenesis of asbestos-related disease, and provide mechanistic links between asbestos-induced cell death, chronic inflammation, and carcinogenesis. Chemopreventive approaches aimed at inhibiting the chronic inflammatory response, and especially blocking HMGB1, may decrease the risk of malignant mesothelioma among asbestos-exposed cohorts."

"Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation" Published online before print June 28, 2010, doi:10.1073/pnas.1006542107 (This item requires a subscription to Proceedings of the National Academy of Sciences).

Click here to read more about asbestos related disease and claims for benefits. 

For over 3 decades the Law Offices of Jon L. Gelman1.973.696.7900 jon@gelmans.com  has been representing injured workers and their families who have suffered asbestos related illnesses.

Quebec to Resuscitate Its Asbestos Industry

Despite a public outcry and world wide outrage, the Quebec government is now poised to infuse the Province's idle asbestos mining industry with financial support to bring it back to life.  The Montreal Gazette reports that the cabinet of Quebec Premiere Jean Charest's cabinet is about to approve a $58 Million loan to activate the Jeffry Mine in Asbestos, Quebec. The mine has been idle since 2002. Asbestos is a known carcinogen that has been causally linked to lung cancer and mesothelioma, a rare and fatal malignancy. Hundreds of thousands of claims have been filed against the asbestos industry for direct liability. Verdicts continue to be reported in record number in cases filed by asbestos victims and their families. While asbestos use has been banned in many countries, Canada and the United States have yet to ban is use.  Click here to read more about asbestos related disease and claims for benefits. For over 3 decades the Law Offices of Jon L. Gelman1.973.696.7900 jon@gelmans.com  has been representing injured workers and their families who have suffered asbestos related illnesses.