IMIG 2014: Dr. Robert Weinberg speaks on Cancer Stem Cell Targeting Therapies

Dr. Weinberg focused on the importance of cancer stem cells in mesothelioma. The concept of a stem cell origin of cancer was first described over fifty years ago as a small subset of cells capable of re-initiating a clonal tumor, and there is evidence for both a stem cell origin of mesothelioma, and a stem cell population in the mesothelioma tumor microenvironment. These cells play an essential role in the invasion-metastasis cascade, they are risk to conventional chemotherapy, and are believed to underlie resistance and relapse in mesothelioma. Click here for a summary of the latest information on cancer stem cells in mesothelioma.

Click here to watch Dr. Weinberg’s Presentation

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IMIG 2014: Mesothelioma: Cancer stem cells by defactinib, a novel inhibitor of FAK

Paul Baas summarizes evidence from studies showing specific targeting of cancer stem cells by defactinib, a novel inhibitor of FAK.

Click here to watch Paul Baas

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IMIG 2014: Dr. Ravi Salgia presents “From Chaos to Mitochondrial Functionality”

Dr. Salgia summarized efforts from his group to bring mathematical modeling to the study of malignant mesothelioma and how the rules of this theory can be applied to consideration of mutations associated with mesothelioma, suggesting that DNA acts much likes fractals. He emphasized that the fractal dimensionality of mesothelioma cells is dramatically different from that of normal cells and that mitochondrial networks in mesothelioma can also be modeled with fractal analysis. Click here to learn more about this new approach to understanding mesothelioma and the biology of other cancer cells.

Click here to watch Dr. Salgia’s Presentation

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IMIG: Dr. Constantine Alifrangis Speaks on Next Generation Sequencing in Mesothelioma

Dr. Constantine Alifrangis focused on the study of cancer genomes and how it might be used to identify new treatments and individualize care for patients with mesothelioma. These approaches have identified specific genomic alterations in mesothelioma associated with unexpected drug sensitivities in mesothelioma. As for other cancers, study of cancer genomes in mesothelioma has the potential to guide development of novel therapies for this disease.Click here to hear and see more about this work.

Click here to watch Dr. Alifrangis’s Presentation

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