IMIG 2014: Dr. Robert Weinberg speaks on Cancer Stem Cell Targeting Therapies

Dr. Weinberg focused on the importance of cancer stem cells in mesothelioma. The concept of a stem cell origin of cancer was first described over fifty years ago as a small subset of cells capable of re-initiating a clonal tumor, and there is evidence for both a stem cell origin of mesothelioma, and a stem cell population in the mesothelioma tumor microenvironment. These cells play an essential role in the invasion-metastasis cascade, they are risk to conventional chemotherapy, and are believed to underlie resistance and relapse in mesothelioma. Click here for a summary of the latest information on cancer stem cells in mesothelioma.

Click here to watch Dr. Weinberg’s Presentation

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IMIG 2014: Mesothelioma: Cancer stem cells by defactinib, a novel inhibitor of FAK

Paul Baas summarizes evidence from studies showing specific targeting of cancer stem cells by defactinib, a novel inhibitor of FAK.

Click here to watch Paul Baas

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Petition Aims to Build First Federally Funded Mesothelioma Program

Helping asbestos victims may become a Federal effort. Today's post was shared by Linda Reinstein and comes from www.asbestos.com

As the youngest person to become chief of Naval Operations, Admiral Elmo Zumwalt played a major role in U.S. military history -- a war hero whose service spanned World War II, Korea and Vietnam. It's only appropriate that the Mesothelioma Center for Excellence at the VA West Los Angeles Medical Center is adopting his name. Zumwalt died from pleural mesothelioma cancer almost 14 years ago, an ending that far too many veterans have suffered, stemming from the once-extensive use of asbestos in the armed forces. His life was dedicated to those who bravely served their country. Now his memory will be, too. If the efforts to become the first federally funded mesothelioma program are successful, the Elmo Zumwalt Treatment & Research Center in Los Angeles is expected to blossom and become a premier destination for veterans battling this disease. "These (veterans) are our heroes. They've given so much of themselves. They deserve the best care we can give them, particularly with this disease," said Clare Cameron, executive director of the nearby Pacific Heart, Lung and Blood Institute. "I think it is so important to take care of them now. They have earned that right." Help With Petition Signatures Cameron has been gathering petition signatures supporting efforts by the West Los Angeles VA and the Zumwalt family. She will present the petition early in 2014 to Robert Petzel, M.D., Under Secretary for Health for the U.S....

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Malignant Mesothelioma Treatment (PDQ®)

Today's post was shared by Linda Reinstein and comes from www.cancer.gov

Malignant mesothelioma is a disease in which malignant (cancer) cells form in the lining of the chest or abdomen. Malignant mesothelioma is a disease in which malignant (cancer) cells are found in the pleura (the thin layer of tissue that lines the chest cavity and covers the lungs) or the peritoneum (the thin layer of tissue that lines the abdomen and covers most of the organs in the abdomen). This summary is about malignant mesothelioma of the pleura. Respiratory anatomy; drawing shows right lung with upper, middle, and lower lobes; left lung with upper and lower lobes; and the trachea, bronchi, lymph nodes, and diaphragm. Inset shows bronchioles, alveoli, artery, and vein. Being exposed to asbestos can affect the risk of malignant mesothelioma. Anything that increases your chance of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn’t mean that you will not get cancer. Talk to your doctor if you think you may be at risk. Many people with malignant mesothelioma have worked or lived in places where they inhaled or swallowed asbestos. After being exposed to asbestos, it usually takes a long time for malignant mesothelioma to form. Other risk factors for malignant mesothelioma include the following: Possible signs of malignant mesothelioma include shortness of breath and pain under the rib cage. Sometimes the cancer causes fluid to collect around the lung or in the abdomen. These symptoms may...

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